By I. M. Pulkina, P.S. Kuznetsov
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Extra info for A Short Russian Reference Grammar: with a Chapter on Pronunciation
Urinary clearance is larger than GFR for substances, which are both ﬁltered and secreted. Creatinine Creatinine is the most commonly used marker for the assessment of renal function. • It derives from muscle catabolism, and meat or creatine intake, and hence varies according to body muscle mass and food intake. • With a molecular weight of 113 Da it is freely ﬁltered by the glomerulus. As it is additionally secreted by the tubules, creatinine clearance systemically overestimates the GFR, particularly in patients with impaired renal function.
Collection of urine samples The method of obtaining and handling urine specimens has a great effect on the result. It is therefore essential to standardize these procedures as far as possible. • The patient should not perform arduous physical exercise for 72 h before collecting the urine, otherwise proteinuria, hematuria or cylindruria might be induced. • Urinalysis should not be performed in females during menstruation because of possible blood contamination. • The first or second morning urine is preferred for analysis.
5–30 mg/mmol in women). It is a typical early albeit nonspecific feature of diabetic or hypertensive nephropathy. Tubular proteinuria. This is characterized by the presence of low molecular weight proteins, which are normally ﬁltered in the glomeruli and reabsorbed in the tubules, such as α1-microglobulin or B2-microglobulin. Their increased concentration in the urine indicates tubular damage. Leukocyte esterase Dipstick testing for leukocyturia as a marker for urinary tract infection is based on the activity of leukocyte esterase released from lysed macrophages and neutrophil granulocytes.