By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)
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Additional resources for Advances in Cancer Research, Vol. 15
The cytoplasmic localization of T-antigen in transformed or tumor cells was stable upon multiple passages in vitro. No apparent differences were detected when the properties of cytoplasmic SV40 T-positive cells were compared t o those of nuclear T-positive cells (Richardson and Butel, 1971). A summary of the results of that comparative study is given in Table 11. Although all the available evidence supports the concept that information for the synthesis of SV40 T-antigen resides in the viral genome, the host cell nevertheless does appear to exert some influence upon the expression of the T-antigen.
1968). These variant derivatives exhibited a flattened morphology, attained lower saturation densities, and, with the two variants tested, reduced tumor-producing capacity in vivo. This study included 3T3 mouse cells transformed by either SV40 or polyoma and a hamster tumor cell line originating from a polyoma virus-induced tumor. The variant clones still contained the virus-specific T-antigens and, with a t least one derivative cell line, still yielded infectious SV40 following fusion with monkey kidney cells.
For this reason, the antigen or antigens detected by in vitro tests will be designated as surface or S-antigen(s) . I n this section, we will analyze the S-antigen(s) with respect to their detection, specificity, and nature. Tevethia et al. (1965) first demonstrated S-antigen in SV40-transformed cells by the indirect immunofluorescence test using sera from SV40-vaccinated hamsters that had rejected a transplant of virus-free SV40 tumor cells. Live cells were used in the immunofluorescence test, and the reaction was localized at the cell surface in the form of a ring around the cell (Fig.