By Paul H. Sugarbaker MD, FACS, FRCS (auth.), Santiago González-Moreno MD, PhD (eds.)
S. González-Moreno (Ed. ) Advances in Peritoneal floor Oncology With forty five Figures in fifty seven Separate Illustrations, 12 in colour and 19 Tables 123 IV Preface Santiago González-Moreno, MD, PhD division of Surgical Oncology Centro Oncológico MD Anderson foreign España Calle Gómez Hemans 2 28033 Madrid Spain sgonzalez@mdanderson. es Library of Congress keep an eye on quantity: 2006937141 ISSN 0080-0015 ISBN 978-3-540-30759-4 Springer Berlin Heidelberg ny This paintings is topic to copyright. All rights are reserved, no matter if the full or a part of the cloth is anxious, speci? ?cally the rights of translation, reprinting, reuse of illustrations, recitations, broadcasting, replica on micro? ?lm or in the other means, and garage in facts banks. Duplication of this ebook or components thereof is authorized merely below the provisions of the German Copyright legislation of September nine, 1965, in its present model, and permission to be used should always be bought from Springer-Verlag. Violations are answerable for prosecution less than the German Copyright legislations. Springer is a part of Springer Science+Business Media http//www. springer. com Springer-Verlag Berlin Heidelberg 2007 revealed in Germany using basic descriptive names, emblems, and so on. during this ebook doesn't mean, even within the absence of a speci? ?c sta- ment, that such names are exempt from the correct protecting legislation and laws and hence unfastened for normal use. Product legal responsibility: The publishers can't warrantly the accuracy of any information regarding dosage and alertness contained during this e-book. In each case the person needs to payment such details through consulting the proper literature.
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Additional resources for Advances in Peritoneal Surface Oncology
Clin Cancer Res 6:4234–4242 7. Jacquet P, Sugarbaker PH (1996) Peritoneal-plasma barrier. In Sugarbaker PH (ed) Peritoneal carcinomatosis: principles of management. Kluwer Academic Publisher, Boston, pp 53–63 8. Weiss L (1990) Metastatic inefficiency. Adv Cancer Res 54:159–211 9. Yonemura YC et al. (1997) A possible role of cytokines in the formation of peritoneal dissemination. Int J Oncol 111:349–358D 10. Yonemura Y (1998) Mechanisms of the formation of peritoneal dissemination. In: Yonemura Y, Shoten M (eds) Peritoneal dissemination.
Fig. 6 Histology of a typical low-grade appendiceal mucinous neoplasm (LAMN). Above is much mucin within the subserosal tissues of the appendix whilst low-grade glandular neoplasia, with lowgrade cytological atypia, minimal architectural complexity and no destructive invasion, has come to line the peritoneal surface below 3 Pathological Evaluation and Implications of Serosal Involvement in Gastrointestinal Cancer 33 Fig. 7 Histology of mucinous adenocarcinoma (MACA) of the appendix. Floating within mucin, in a large mucinous mass in the omentum, metastatic from a primary appendiceal tumour, is this complex glandular lesion with high-grade cytoarchitectural atypia Not only will the prognosis of PP depend on the nature of the appendiceal lesion, it will also depend on the extent of peritoneal disease: patients with peritoneal mucinous carcinoma (numerous malignant cells in the mucin) will have a worse prognosis and a higher risk of recurrence than patients with peritoneal adenomucinosis [40, 46].
More obvious evidence of peritoneal involvement is provided by a fibrinous exudate and a coarse irregular serosa. At the time of the macroscopic assessment, it has been recommended that at least two blocks are taken from the most suspicious areas for microscopic assessment . If peritoneal involvement is not evident, at least four levels should be cut through those blocks before peritoneal involvement can be ruled out . The presence of free tumour cells in the peritoneal cavity is usually associated with serosal involvement but may be present even without demonstrable involvement of the serosa.