By Rhonda Yantiss
Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix, a quantity within the Advances in Surgical Pathology sequence, positive aspects chapters on present and coming near near adjustments within the box with an emphasis on sensible matters, fresh advancements, and rising concepts.
Created as a short evaluation for use in the course of pathologic assessment of melanoma specimens from the decrease gastrointestinal tract, this ebook comprises the most recent information about rising endoscopic ideas that relief in tumor class and staging, mechanisms of pathogenesis, and scientific management.
It combines gross and microscopic pictures and hassle-free tables for speedy reference with a succinct, accomplished assessment of concerns very important to administration of sufferers with colorectal carcinoma. not just does it speak about the utilized situation of melanoma epidemiology and prevention, the ebook additionally covers pathological positive factors of melanoma precursors. Plus, an creation to destiny diagnostic and remedy modalities, similar to biomarker research, chemotherapeutic innovations, particular molecular cures, and competitive multidisciplinary techniques to sufferers with complicated degree disease.
- Emphasizes clinically and practically relevant information, including pathology reports and molecular test results
- Covers appropriate surgical anatomy, gross exam, and specimen guidance thoughts to help within the dealing with of surgical resection specimens
- Provides a uncomplicated wisdom of surgical pathology and molecular review of colonic and appendiceal cancer
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Extra resources for Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix
All Rights Reserved. 36 Section II • Cancer Precursors: Colorectal Polyps and Chronic Colitis SESSILE SERRATED POLYPS Clinical and Endoscopic Features of Sessile Serrated Polyps Sessile serrated polyps are nondysplastic polyps that show a predilection for the abdominal colon and, unlike most hyperplastic polyps, are more common among women. 7,17 Sessile serrated polyps are plaques that merge imperceptibly with the adjacent nonlesional mucosa, and, thus, their size may be difficult to appreciate endoscopically.
24 Section I • Introduction HEREDITARY POLYPOSIS SYNDROMES Lynch Syndrome Lynch syndrome (hereditary nonpolyposis colorectal cancer) is the most common colon cancer susceptibility syndrome. As discussed in Chapter 11, it is an autosomal dominant disorder caused by a germline mutation in one of several DNA mismatch repair genes, including MSH2, MLH1, MSH6, PMS1, and PMS2. Patients may have heritable cancers limited to the colorectum or, more classically, an increased risk for a variety of malignancies, including endometrial, ovarian, urologic, gastric, small bowel, pancreatic, and central nervous system tumors.
4. Nguyen SP, Bent S, Chen YH, et al. Gender as a risk factor for advanced neoplasia and colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol [Meta-Analysis Review] 2009;7(6): 676–681; e1–e3. 5. Ben Q, An W, Jiang Y, et al. Body mass index increases risk for colorectal adenomas based on metaanalysis. S. Gov’t] 2012;142(4):762–772. 6. Rex DK, Khan AM, Shah P, et al. Screening colonoscopy in asymptomatic average-risk African Americans. Gastrointest Endosc 2000;51(5):524–527.