Download Alpha-Hydroxy Acids in Enantioselective Syntheses by Gary M. Coppola PDF
By Gary M. Coppola
Recognition man made chemist! Chiral alpha-hydroxy acids to be had from nature's chiral pool function beginning fabrics in a large choice of enantioselective conversions resulting in commercially very important items. This monograph, a stimulating resource of principles and an important reference paintings for study chemists, specializes in the well known lactic, mandelic, malic, and tartaric acids. Well-chosen examples convey how chiral facilities inherent in those easy compounds can be utilized to manage the advent of extra stereogenic facilities. Readers can without delay practice new ameliorations of their personal paintings on account that response stipulations are given in convenient tables.
Read or Download Alpha-Hydroxy Acids in Enantioselective Syntheses PDF
Best physical chemistry books
Deals an built-in assessment of enzyme use in loved ones detergents, from product improvement and production to protection and health-related concerns. The textual content information the key kinds of enzymes, structure-function relationships, lifestyles cycle analyses, protein-engineering suggestions, cleansing mechanisms, and prior, current and destiny purposes.
Handbook of microemulsion science and technology
Demonstrating equipment for overcoming balance matters in paints, wax dispersions, cosmetics, foodstuff items, and different commercial purposes, this reference probes theoretical and sensible concerns surrounding microemulsion technological know-how and expertise. that includes the paintings of fifty one overseas specialists and containing virtually one thousand instructive tables, equations, and illustrations, this publication studies the functionality of, and clients for, experimental equipment reminiscent of X-ray diffraction, transmission electron microscopy (TEM), gentle scattering, small attitude neutron scattering, viscosimetry, and nuclear magnetic resonance (NMR) to represent quite a few facets of the dispersed section of microemulsions.
A Configurational Model of Matter
The e-book we're proposing to American and different English talking readers is a overview of the paintings at the electron struc ture of parts, alloys, and compounds, which was once begun again within the fifties. This paintings progressively grew right into a method of rules at the electron constitution of condensed subject that is referred to now because the configurational version.
Physical Chemistry and Acid-Base Properties of Surfaces
The 1st a part of this booklet seems on the outcome of chemical and topological defects current on genuine surfaces, which clarify the wettability of tremendous hydrophilc and great hydrophobic surfaces. There follows an in-depth research of the acido-basicity of surfaces with, for instance, various wettability experiments on actual fabrics.
- Electronic Structure Calculations on Graphics Processing Units: From Quantum Chemistry to Condensed Matter Physics
- Molecular and Colloidal Electro-optics (Surfactant Science)
- Computational Photochemistry, Volume 16 (Theoretical and Computational Chemistry)
- Advances in Chemical Physics, Volume 108: Global and Accurate Vibration Hamiltonians from High-Resolution Molecular Spectroscopy
- Higher Excited States of Polyatomic Molecules: v. 1
- Chiral Photochemistry (Molecular and Supramolecular Photochemistry)
Extra info for Alpha-Hydroxy Acids in Enantioselective Syntheses
Example text
5]decane is a pheromone produced by two varieties of bees, Parvespula vulgaris L. and Andrena haemorrhoa F. The 2R, 5R, 7/^-isomer (188) has been synthesized using 147, ultimately derived from ethyl L-lactate, to supply the chiral stereocenter at C-2 (Scheme 26) [19]. The second chiral intermediate 185 is derived from (S)-( — )-malic acid. 6% starting from 184, and the optical purity of the final product is 96%. 4), and the enantiomer of 185, available from (*S)-malic acid. 3 O-(Trifluoromethanesulfonyl) L-Lactic Acid Derivatives OS02CF3 (S)-2-[[(Trifluoromethyl)sulfonyl]oxy]propanoic Acid The enhanced leaving ability of the triflate group allows SN2 substitution reactions to occur at lower temperatures and over shorter periods of time relative to other leaving groups.
MS CH3COSCs J^ CHs H 3% HCI, BOH 90% C 95% 168 156b 169 The properties of cesium salts can be taken advantage of to convert ( Alternately, ethyl L-lactate can be benzylated without racemization using benzyl trichloroacetimidate [94,95]; however, this reagent is rather expensive. (S)-2-Benzyloxylactic acid (274) is accessible in two steps via asymmetric alkylation of glycolic acid derivative 272. Methylation of 272 proceeds in high yield to give 273 with 97% de. H PhCH2Br OCH2Ph Ag2O CH;T 9H CI3C(NH)OCH2Ph COOR TFA (cat) 63% CH3" 69% 271 a R = CH3 271b R= B 2 triflate can also be used to obtain products with greater than 96% de [96].