Download Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: by A. Gullo PDF

Download Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: by A. Gullo PDF

By A. Gullo

Bettering criteria of care is a true problem in in depth Care drugs. improving scientific functionality, sufferer defense, threat administration and audit represents the cornerstone for elevating the standard of care in ICU sufferers. verbal exchange is the platform from the place to begin to arrive a consensus in an exceptionally crowded quarter, a different multidisciplinary and multiprofessional setting within which caliber of care and, eventually, sufferer survival must be ameliorated.

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Read or Download Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: Proceedings of the 22st Postgraduate Course in Critical Medicine Venice-Mestre, Italy - November 9-11, 2007 PDF

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Additional resources for Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: Proceedings of the 22st Postgraduate Course in Critical Medicine Venice-Mestre, Italy - November 9-11, 2007

Sample text

The reason is obvious: Microdialysis is a diagnostic technique not a treatment. A proper outcome study can only be performed when the data derived from microdialysis is used to guide a treatment known to be effective. This could be the adjustment of cerebral perfusion pressure (CPP) in response to the lactate/pyruvate ratio in order to increase capillary perfusion, or changing the dose of a drug in response to the PK/PD in the tissue. In all such situations the purpose is to individualize the treatment in relation to the biochemistry of the tissue.

In the case of microdialysis we implant our microdialysis catheter in the particular tissue or organ of interest. It means that if we want to study, for example, changes in the energy metabolism, we can use the same marker substances for whichever organ we study. We monitor the environment of the cells in the organ regardless of whether the substances are produced from the cells themselves or imported from the local capillary blood flow. We sample the environment that tells us if the cells are functioning normally, if they are being supplied normally, the drug concentrations they are exposed to and the pathology they are suffering.

In the case of microdialysis we implant our microdialysis catheter in the particular tissue or organ of interest. It means that if we want to study, for example, changes in the energy metabolism, we can use the same marker substances for whichever organ we study. We monitor the environment of the cells in the organ regardless of whether the substances are produced from the cells themselves or imported from the local capillary blood flow. We sample the environment that tells us if the cells are functioning normally, if they are being supplied normally, the drug concentrations they are exposed to and the pathology they are suffering.

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