By Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann
content material: melanoma drug discovery and improvement : new paradigms for a brand new millennium / E.A. Sausville ... [et al.] --
Evolutionary biosynthesis of anticancer medicinal drugs / George R. Pettit --
a few fresh advancements within the synthesis and structure-activity courting of novel taxanes / John F. Kadow ... [et al.] --
New iteration taxoids and hybrids of microtubule-stabilizing anticancer brokers / Iwao Ojima ... [et al.] --
Discodermolide and taxol : a synergistic drug mixture in human carcinoma mobilephone traces / Susan Band Horwitz ... [et al.] --
hugely effective semisynthesis of biologically energetic epothilone derivatives / Gregory D. Vite ... [et al.] --
artificial and semisynthetic analogs of epothilones : chemistry and organic task / Karl-Heinz Altmann ... [et al.] --
Synthesis and organic job of epothilones / Ulrich Klar ... [et al.] --
Epothilones and sarcodictyins : from combinatorial libraries to designed analogs / Nicolas Winssinger and K.C. Nicolaou --
Synthesis and structure-activity dating reviews of cryptophycins : a unique type of effective antimitotic antitumor depsipeptides / Chuan Shih ... [et al.] --
Farnesyltransferase inhibitors as strength anticancer brokers / J.B. Gibbs ... [et al.] --
Farnesyltransferase inhibitors : from squalene synthase inhibitors to the medical agent BMS-214662 / John T. Hunt --
Inhibiting farnesyl protein transferase with Sch-66336 : probably a selective noncytotoxic remedy for human melanoma / A.G. Taveras ... [et al.] --
Pyrrolo[2,3-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives as selective inhibitors of the EGF receptor tryosine kinase / G. Caravatti ... [et al.] --
STI571 : a brand new therapy modality for CML? / Jürg Zimmermann, Pascal Furet, and Elisabeth Buchdunger --
the invention and improvement of second-generation matrix metalloproteinase inhibitors for the remedy of melanoma / Andy Baxter and John Montana --
customers for antiangiogenic cures dependent upon VEGF inhibition / Pascal Furet and Paul W. Manley --
Carbohydrate-based tumor antigens as antitumor vaccine brokers / Jennifer R. Allen and Samuel J. Danishefsky --
medications to reinforce the healing efficiency of anticancer antibodies : antibody-drug conjugates as tumor-activated prodrugs / Walter A. Blättler and Ravi V.J. Chari.
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Additional resources for Anticancer Agents. Frontiers in Cancer Chemotherapy
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The alpha diol 29 was prepared stereospecifically as previously described (Scheme 2) (42, 45). Selective oxidation of the more accessible 6-hydroxy group using a TEMPO based oxidation provided the hydroxy ketone 30 in high yield. Fortuitously, the C-7 hydroxy group epimerized upon exposure to silica gel to exclusively produce the desired configuration at C-7. Reduction with triacetoxy borohydride provided only the beta diol 31 which was unavailable from direct hydroxylation of the olefin. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2001.
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