Download Anticancer Agents. Frontiers in Cancer Chemotherapy by Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann PDF

Download Anticancer Agents. Frontiers in Cancer Chemotherapy by Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann PDF

By Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann

content material: melanoma drug discovery and improvement : new paradigms for a brand new millennium / E.A. Sausville ... [et al.] --
Evolutionary biosynthesis of anticancer medicinal drugs / George R. Pettit --
a few fresh advancements within the synthesis and structure-activity courting of novel taxanes / John F. Kadow ... [et al.] --
New iteration taxoids and hybrids of microtubule-stabilizing anticancer brokers / Iwao Ojima ... [et al.] --
Discodermolide and taxol : a synergistic drug mixture in human carcinoma mobilephone traces / Susan Band Horwitz ... [et al.] --
hugely effective semisynthesis of biologically energetic epothilone derivatives / Gregory D. Vite ... [et al.] --
artificial and semisynthetic analogs of epothilones : chemistry and organic task / Karl-Heinz Altmann ... [et al.] --
Synthesis and organic job of epothilones / Ulrich Klar ... [et al.] --
Epothilones and sarcodictyins : from combinatorial libraries to designed analogs / Nicolas Winssinger and K.C. Nicolaou --
Synthesis and structure-activity dating reviews of cryptophycins : a unique type of effective antimitotic antitumor depsipeptides / Chuan Shih ... [et al.] --
Farnesyltransferase inhibitors as strength anticancer brokers / J.B. Gibbs ... [et al.] --
Farnesyltransferase inhibitors : from squalene synthase inhibitors to the medical agent BMS-214662 / John T. Hunt --
Inhibiting farnesyl protein transferase with Sch-66336 : probably a selective noncytotoxic remedy for human melanoma / A.G. Taveras ... [et al.] --
Pyrrolo[2,3-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives as selective inhibitors of the EGF receptor tryosine kinase / G. Caravatti ... [et al.] --
STI571 : a brand new therapy modality for CML? / Jürg Zimmermann, Pascal Furet, and Elisabeth Buchdunger --
the invention and improvement of second-generation matrix metalloproteinase inhibitors for the remedy of melanoma / Andy Baxter and John Montana --
customers for antiangiogenic cures dependent upon VEGF inhibition / Pascal Furet and Paul W. Manley --
Carbohydrate-based tumor antigens as antitumor vaccine brokers / Jennifer R. Allen and Samuel J. Danishefsky --
medications to reinforce the healing efficiency of anticancer antibodies : antibody-drug conjugates as tumor-activated prodrugs / Walter A. Blättler and Ravi V.J. Chari.

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Chem. Soc. 1998, 120, 12980-12981. Patel, R. M. Annu. Rev. Microbiol. 1998, 98, 361-395. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2001. 19. ; Wall, Μ . Ε. , E d . , C R C Press: N Y , 1995; Chapter 1, pp 3-22. 20. ; Hurley, L. H. J. Med. Chem. 1999, 42, 2493-2497. 21. Forsyth, C . J . ; Cink, R. D . ; Lee, C . S. J. Am. Chem. Soc. 1998, 120, 5597-5598. 22. Dhokte, U . ; Khau, V . ; Hutchison, D . ; Martinelli, M. J. Tetrahedron Lett. 1998, 8771-8774. 23. Nicolaou, K . C .

The alpha diol 29 was prepared stereospecifically as previously described (Scheme 2) (42, 45). Selective oxidation of the more accessible 6-hydroxy group using a TEMPO based oxidation provided the hydroxy ketone 30 in high yield. Fortuitously, the C-7 hydroxy group epimerized upon exposure to silica gel to exclusively produce the desired configuration at C-7. Reduction with triacetoxy borohydride provided only the beta diol 31 which was unavailable from direct hydroxylation of the olefin. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2001.

Hamel, E . Biochemistry 1995, 34, 9714-9721. Hayward, M. ; Roth, R. ; Duffy, K . J . ; Dalko, P. ; Stevens, K . ; Guo, J . ; Kishi, Y. Angew. Chem. Int. Ed. 1998, 37, 192-196. Evans, D . ; Trotter, B . W . ; Coleman, P. ; Côté, B . ; Dias, L. ; Rajapakse, H . ; Tyler, A. N. Tetrahedron 1999, 55, 8671-8726. Pettit, G . ; Herald, C . ; Tuinman, Α. ; Boettner, F . E . ; Schmidt, J. ; Tomer, Κ. B . ; Bontems, R. J. J. Am. Chem. Soc. 1987, 109, 6883-6885. Pettit, G . ; Singh, S. B . ; Herald, D . ; Burkett, D .

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