By Syed A. Abutalib, Maurie Markman
The box of oncology advantages from numerous large-scale reference books and a number of monographs devoted to particular cancers. despite the fact that, actually very good perform and evaluate books are, unusually, rather scarce. open air of a scant handful of books and on-line reference instruments that provide scientific reaction perform and board evaluate in a simple query and solution layout, there are not any assets that supply a powerful, attractive, absolutely referenced software for those important actions in each oncologist’s and oncology trainee’s paintings. This print and digital ebook seeks to fill that void, delivering entire question-and-answer sort content material that covers the total strong point of oncology and gives training oncologists with a desirable and instantly appropriate compendium of important details facing a well-balanced choice of universal and unusual cancers. on the center of this publication is the editor’s and authors’ wish to conquer the controversies and obstacles to perform that sometimes emerge following the looks of recent facts. In each part, the person is guided towards collaboration in ongoing scientific examine – for instance, through discussions of well-designed ongoing scientific trials in every one particular area.
Developed with either the instructor and learner in brain, this publication additionally deals trainees and fellows an exceptional chance to augment their education for the ABIM oncology fellowship examination in addition to for the oncology forums. it's going to even be an exceptionally useful gizmo for oncologists operating towards the recertification examination. This accomplished, beefy booklet contains countless numbers of painstakingly built multiple-choice and mini-case-based questions overlaying the rules of clinical oncology, malignant hematology, surgical oncology, and radiation oncology. It additionally includes mini-cases and questions facing the biology, analysis, class, staging, and multidisciplinary therapy of cancers at each anatomic web site. The very newest themes are integrated, akin to molecular recommendations, distinct remedies, and translational melanoma examine. Concise yet certain solutions are referenced to key journals and books, and evidence-based at any place attainable. NCCN directions also are referenced as acceptable. With its robust specialise in take-home messages from and for genuine scientific paintings, this booklet may help maintain oncologists modern, bridging the gaps among magazine and reference literature, meetings, and their current wisdom base.
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Extra resources for Cancer consult : expertise for clinical practice
Is the WBC still of prognostic relevance with the cytogenetic and genetic markers now available? Elevated WBC at diagnosis (>30,000–50,000/ml) as a poor prognostic feature has been confirmed in various trials. It was even considered as the most deleterious prognostic factor in B-precursor ALL with overall survival of 19–29%. The biological reason for the highly resistant behavior of B-precursor ALL with high WBC is unclear. Probably in the future, additional molecular markers can help to clarify the underlying mechanisms.
There is a strong correlation of outcome to the immunophenotypic subtypes cortical-thymic T-ALL versus early T-ALL or mature T-ALL. Thymic T-ALL is CD1apositive and constitutes about half of adult T-ALL patients; their survival at 5 years is >50–60%. The subtypes early T-ALL and mature T-ALL have a lower rate of CR and a poorer survival; both subtypes profit from an allo-SCT in CR1. • Are genetic markers in T-lineage superseded by the prognostic impact of the immunophenotypic T-ALL subtypes? It seems that the relevance of immunophenotype is even underlined by genetic markers; in fact, the overexpression of HOX11, HOX11L2, SILTAL1, and CALM–AF10 is associated with subtypes, that is, maturation states of thymocytes.
The genetic basis of early T-cell precursor acute lymphoblastic leukemia. Nature. 2012;481:157–63. Zaremba CM, Oliver D, Cavalier M, et al. Distinct immu nophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations. Ann Diagnostic Pathol. 2012;16:16–20. CHAPTER 2 Prognostic markers and models in acute lymphoblastic leukemia Dieter Hoelzer University Hospital, Frankfurt am Main, Germany Acute lymphoblastic leukemia (ALL) is not a uniform disease but is characterized by subgroups with different biological and clinical features and cure rates.