Download Cancer Cytogenetics: Chromosomal and Molecular Genetic by Sverre Heim, Felix Mitelman PDF

Download Cancer Cytogenetics: Chromosomal and Molecular Genetic by Sverre Heim, Felix Mitelman PDF

By Sverre Heim, Felix Mitelman

The 1st 3 versions of this acclaimed ebook offered a much-needed conceptual synthesis of this speedily relocating box. Now, Cancer Cytogenetics, Fourth version, bargains a entire, increased, and updated assessment of contemporary dramatic advances during this sector, incorporating an unlimited quantity of recent info from the most recent simple and medical investigations.

  • New participants reflecting broader foreign authorship or even larger expertise
  • Greater emphasis all through at the medical significance and alertness of data approximately cytogenetic and molecular aberrations
  • Includes a whole assurance of chromosome aberrations in melanoma in accordance with an overview of the 60,000 neoplasms cytogenetically investigated to date
  • Now produced in complete colour for superior clarity
  • Covers how molecular genetic facts (PCR-based and sequencing details) are collated with the cytogenetic info the place pertinent
  • Discusses how molecular cytogenetic info (based on reviews utilizing FISH, CGH, SNP, and so on) are fused with karyotyping facts to allow an as entire realizing of melanoma cytogenetics as is at present possible

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Extra info for Cancer Cytogenetics: Chromosomal and Molecular Genetic Aberrations of Tumor Cells

Sample text

The leukemias and malignant lym­ phomas make up three‐fourths of all cases but cause only 10% of human cancer deaths, whereas the major cancer killer, the malignant epithelial tumors responsible for 90% of cancer mortality, is represented by less than 10% of the cases in the database. In fact, we know less about the cytoge­ netics of all carcinomas today than we did about one leukemia subtype, acute myeloid ­leukemia, 20 years ago. In addition, there are technical and analytical problems that limit the information value of the existing cytogenetic data on malignant epithelial tumors.

Second, investigations of carcinomas have often been performed late in the disease, on samples from effusions or metastases, that is, at a time when the karyotype may be dominated by complex secondary karyotypic changes (see the following text) accrued during tumor progression. , 2001). All these circumstances compound the difficulties in pinpointing the essential genomic rearrangements in early tumor development. More cytogenetic data are therefore particularly badly needed for epithelial neoplasms.

Much of the interest in the connection between fragile sites and cancer consequently cooled off (see Heim and Mitelman, 1995, for a review of the early data). Recent findings have again linked common fragile sites to chromosome rearrangements and tumori­ genesis, however. , 2010). The results provide evidence that the involvement of chromosomal fragile sites in the generation of cancer‐specific chromosome abnormalities is not fortuitous. At present, the bulk of available evidence therefore again appears to indi­ cate that inherited or acquired genomic instability generated by formation of DNA breaks and/or failure of cell cycle checkpoints facilitates the appear­ ance of chromosome aberrations and predisposes individuals to develop various cancers.

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