Download Cancer du testicule by Alain Houlgatte PDF

Download Cancer du testicule by Alain Houlgatte PDF

By Alain Houlgatte

Le melanoma du testicule a bénéficié d'importantes avancées thérapeutiques transformant radicalement son pronostic. Cet ouvrage aborde les différents progrès ideas tant dans le domaine du diagnostic - avec l'apport de l'imagerie moderne et de l'anatomopathologie - que thérapeutique. los angeles position de los angeles chimiothérapie de même que celle de l. a. chirurgie sont largement détaillées, plaçant ainsi l'urologue au cœur de l'équipe pluridisciplinaire prenant en cost ces sufferers.

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Extra resources for Cancer du testicule

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Piolat C, Dyon JF, Chavanis N et al. (2003) Hyperplasie des cellules de Leydig chez l’enfant. Prog Urol 13 (1): 110-3 23. Konrad D (1999) Schoenle EJ Ten-year selective follow-up in a boy with Leydig cell tumor after selective surgery. Horm Res 51: 96-100 24. Ritchey M, Pediatric Urologic Oncology. In: Campbell’s Urology 25. Goswitz JJ, Pettinato G, Manivel JC (1996) Testicular sex cord stromal tumors in children. Pediatr Pathol Lab Med 16 (3): 451-70 26. Chang B, Borer JG, Tan PE et al. (1998) Large-cell calcifying Sertoli cell tumor of the testis : case report and review of the literature.

Dans ce cas, il faut évoquer les diagnostics différentiels beaucoup plus fréquents que la tumeur à cellule de Leydig : les pathologies de l’axe hypothalamo-hypophysaire, les nodules testiculaires hyperplasiques en cas d’hyperplasie congénitale des surrénales, et l’hyperplasie des cellules de Leydig (pas de sécrétion anormale en dehors de la testostérone) (22). Il n’y a pas de caractéristiques d’imagerie indiscutable pour ces tumeurs. L’orchidectomie semble la règle, même si ces tumeurs ne sont pas malignes, en raison de rechutes possibles après énucléation (4, 22, 23, 24).

3. L’étude la plus récente, issue du même organisme, à propos d’une centaine de cancers familiaux, a permis de localiser un gène de prédisposition en Xq27, appelé TCGT1 (Testicular Germ Cell Tumour 1). En Xq27, un des gènes candidats est FMR 1 qui est responsable du syndrome de l’X fragile. Dans ce syndrome, les individus ont une macro-orchidie mais n’ont pas de risque particulier de développer une tumeur testiculaire. Cette localisation pourrait aussi expliquer l’augmentation du risque de cancer du testicule dans le syndrome de Klinefelter (47, XXY), les individus ayant leur chromosome X en deux exemplaires.

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