By Eugene C. Toy, Margaret O Uthman, Edward Uthman, Earl J. Brown
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Extra resources for Case Files: Pathology (Lange Case Files), 2nd edition
C. It is an RNA virus that usually is acquired from contaminated food and water. D. It typically is associated with the formation of Mallory bodies on biopsy. E. When it is acquired in adulthood, more than 85 percent of patients develop chronic hepatitis. 2] A 25-year-old woman develops tender hepatomegaly and hemiballism when walking. Her liver biopsy shows hepatocyte necrosis and inflammatory portal tract infiltrate. Which of the following tests is most likely to yield the diagnosis? A. B. C.
Eds. Pocket Companion to Robbins and Cotran Pathologic Basis of Disease, 7th ed. Philadelphia, PA: Saunders, 2006, 416–21. Del Valle J. Peptic ulcer disease and related disorders. , eds. Harrison’s Principles of Internal Medicine, 16th ed. New York: McGraw-Hill, 2004:1746–62. Liu C, Crawford JM. The gastrointestinal tract. In: Kumar V, Assas AK, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease, 7th ed. Philadelphia, PA: Elsevier Saunders, 2004:804–9, 816–27. This page intentionally left blank ❖ CASE 3 A 57-year-old man presents with fatigue for several months and has noticed recently that the waistbands of his pants are tight in spite of a 15-lb weight loss.
18 CASE FILES: PATHOLOGY ANSWERS TO CASE 2: PEPTIC ULCER DISEASE Summary: A 30-year-old man has acute onset of midepigastric pain somewhat relieved by eating. Upper endoscopy reveals a 2-cm gastric ulcer. ◆ ◆ Most likely diagnosis: Peptic ulcer disease. Long-term complications: Erosion or perforation with bleeding; gastric carcinoma in patients with chronic gastritis. ◆ Most likely mechanism: Most often associated with Helicobacter pylori organisms that produce bacterial urease and protease, damaging the mucus layer and exposing the underlying epithelium to acid-peptic injury.