Download Cell Cycle Deregulation in Cancer by Elena Sotillo, Xavier Graña (auth.), Greg H. Enders (eds.) PDF

Download Cell Cycle Deregulation in Cancer by Elena Sotillo, Xavier Graña (auth.), Greg H. Enders (eds.) PDF

By Elena Sotillo, Xavier Graña (auth.), Greg H. Enders (eds.)

Modern experiences of rules of the phone department cycle have been pioneered by way of Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This paintings pointed out proteins termed cyclins that fluxuate in abundance in the course of development throughout the cycle and companion with Cyclin based kinases (Cdks) to force significant phone cycle transitions. a lot has been realized on account that approximately how those and different proteins keep an eye on mobilephone cycle development in all eukaryotes, together with guy. extra examine is uncovering how those controls are de-regulated in melanoma, a ailment of unbridled mobilephone proliferation that's the major reason behind loss of life in constructed nations. although, there's even more to be realized, and the not easy gained earnings are only commencing to influence melanoma care. In eleven reports by means of prime specialists, this quantity lays out the present nation and instructions of the sector for biomedical scientists of all education levels.

The assortment starts with 3 experiences that delineate how cells start up the phone cycle, from development issue stimulation to activation of key transcription courses and origins of DNA replication. the following 3 studies deal with problems with proliferation below duress, together with how derangement of mitotic checkpoints can result in phone loss of life or genetic instability and the way recycling of intracellular molecules (autophagy) is regulated. the subsequent 3 reports handle the specific context of long term proliferation—how it truly is regulated in stem cells, the way it can erode telomeric constructions at the guidance of chromosomes, and the way it may possibly culminate in senescence. The final stories describe how phone cycle advances are commencing to contact sufferers, within the characterization of pre-malignant states and in melanoma therapy.

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Extra resources for Cell Cycle Deregulation in Cancer

Sample text

E2F controls the expression of many genes that are required for cells to divide and elevated E2F activity is found in most tumor cells. The activation and inactivation of E2F are tightly linked to the activation of cyclin-dependent kinases (CDKs). In normal cells, these connections allow the periodic oscillations in CDK cycle to be coupled with temporal programs of gene expression. Multiple CDK–cyclin complexes (including CDK1/2–CycA, CDK1/2– CycB, and CDK7–CycH) have been shown to directly phosphorylate E2F or its dimerization partner DP.

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2004) E2F target genes: unraveling the biology. Trends Biochem Sci 29: 409–417. Burkhart DL, Sage J (2008) Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 8: 671–682. Campanero MR, Flemington EK (1997) Regulation of E2F through ubiquitin-proteasomedependent degradation: stabilization by the pRB tumor suppressor protein. Proc Natl Acad Sci U S A 94: 2221–2226. Chen HH, Wang YC, Fann MJ (2006) Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.

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