Download Delivery of Protein and Peptide Drugs in Cancer by Vladimir P Torchilin PDF

Download Delivery of Protein and Peptide Drugs in Cancer by Vladimir P Torchilin PDF

By Vladimir P Torchilin

Written by way of top scientists within the box of supply of protein and peptide medicines to tumors for melanoma treatment, this crucial publication presents a huge advent to the sphere, with dialogue by way of key specialists at the physiological obstacles for protein and peptide medications in tumors, and different techniques to stabilization of those medicinal drugs in organic atmosphere, in addition to their more suitable supply to tumors and within melanoma cells.

This publication can be utilized as a sophisticated textbook through graduate scholars and younger scientists and clinicians on the early phases in their occupation. it's also appropriate for non-experts from comparable components of chemistry, biochemistry, molecular biology, body structure, experimental and medical oncology and pharmaceutical sciences, who're attracted to common difficulties of drug supply and drug concentrating on in addition to in a extra really expert issues of utilizing protein and peptide medicinal drugs for tumor remedy.

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Extra resources for Delivery of Protein and Peptide Drugs in Cancer

Sample text

59. Zlotecki RA, et al. (1993) Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure. Cancer Res 53:2466–2468. ch02 February 17, 2006 14:18 WSPC/SPI-B359: Delivery of Protein and Peptide Drugs in Cancer (Kim Wei) Influence of Tumor Physiology on Delivery of Therapeutics 33 60. Less JR, et al. (1997) Geometric resistance and microvascular network architecture of human colorectal carcinoma. Microcirculation 4(1):25–33. 61. Milosevic M, et al. (2001) Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygenation measurements.

Studies have shown that cationic liposomes (approx. 49–51 The same issue holds true for micelles, nanoparticles ch02 February 17, 2006 14:18 16 WSPC/SPI-B359: Delivery of Protein and Peptide Drugs in Cancer (Kim Wei) Campbell and other potential carriers of peptide and protein therapeutics of a similar size and charge. The next barrier limits the extent to which drugs can penetrate the tumor interstitium and thus reach their intended cellular targets. Barrier #4 is elevated, interstitial fluid pressure (IFP) also known as interstitial hypertension.

13. Gorog P and Pearson JD (1985) Sialic acid moieties on surface glycoproteins protect endothelial cells from proteolytic damage. J Pathol 146:205–212. 14. Hallmann R, et al. (2005) Expression of function of laminins in the embryonic and mature vasculature. Physiol Rev 85:979–1000. 15. Sund M, Xie L and Kalluri R (2004) The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis. APMIS 112(7–8):450–462. 16. Ruoslahti E (1988) Structure and biology of proteoglycans.

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