By Vladimir P Torchilin
Written by way of top scientists within the box of supply of protein and peptide medicines to tumors for melanoma treatment, this crucial publication presents a huge advent to the sphere, with dialogue by way of key specialists at the physiological obstacles for protein and peptide medications in tumors, and different techniques to stabilization of those medicinal drugs in organic atmosphere, in addition to their more suitable supply to tumors and within melanoma cells.
This publication can be utilized as a sophisticated textbook through graduate scholars and younger scientists and clinicians on the early phases in their occupation. it's also appropriate for non-experts from comparable components of chemistry, biochemistry, molecular biology, body structure, experimental and medical oncology and pharmaceutical sciences, who're attracted to common difficulties of drug supply and drug concentrating on in addition to in a extra really expert issues of utilizing protein and peptide medicinal drugs for tumor remedy.
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Extra resources for Delivery of Protein and Peptide Drugs in Cancer
59. Zlotecki RA, et al. (1993) Effect of angiotensin II induced hypertension on tumor blood ﬂow and interstitial ﬂuid pressure. Cancer Res 53:2466–2468. ch02 February 17, 2006 14:18 WSPC/SPI-B359: Delivery of Protein and Peptide Drugs in Cancer (Kim Wei) Inﬂuence of Tumor Physiology on Delivery of Therapeutics 33 60. Less JR, et al. (1997) Geometric resistance and microvascular network architecture of human colorectal carcinoma. Microcirculation 4(1):25–33. 61. Milosevic M, et al. (2001) Interstitial ﬂuid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygenation measurements.
Studies have shown that cationic liposomes (approx. 49–51 The same issue holds true for micelles, nanoparticles ch02 February 17, 2006 14:18 16 WSPC/SPI-B359: Delivery of Protein and Peptide Drugs in Cancer (Kim Wei) Campbell and other potential carriers of peptide and protein therapeutics of a similar size and charge. The next barrier limits the extent to which drugs can penetrate the tumor interstitium and thus reach their intended cellular targets. Barrier #4 is elevated, interstitial ﬂuid pressure (IFP) also known as interstitial hypertension.
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